Category Archives: Technology and Society

Economics, Media Criticism, Philosophy, Technology and Society

Fishing for the Future

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…Soylent green. The miracle food of high-energy plankton gathered from the oceans of the world.

Soylent Green, 1973

The New York Times predicts that “if current fishing practices continue, the world’s major commercial stocks will collapse by 2048.” Their solution: lower energy content by eating sardines instead of feeding them to farm-raised salmon.

Mistaking energy content for price is a common mistake. Chew on this: organic lettuce is more expensive than a hamburger.

Wild fish will be eclipsed by farm-raised fish just as farm-raised beef has eclipsed free-range beef. Get used to it, perhaps by preparing to pay an extreme premium for free-range fish. Don’t expect the Chinese middle class to prefer wild cod once a year to farm-raised salmon once a month. Expect the coastal waters to be fenced into fish farms just as the Great Plains was fenced in during the 19th century.

It’s time to manage the pollution and reserve the wild fish parks upcurrent. This tide isn’t going to be turned back by pondering how the old days were until we’re eaten up.

Science And Society, Technology and Society

Better (And Longer) Living

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…through RNA interference:

In monkeys, a single injection of a drug to induce RNA interference against PCSK9 lowered levels of bad cholesterol by about 60 percent, an effect that lasted up to three weeks. Alnylam Pharmaceuticals, the biotechnology company that developed the drug, hopes to begin testing it in people next year.

The drug is a practical application of scientific discoveries that are showing that RNA, once considered a mere messenger boy for DNA, actually helps to run the show. The classic, protein-making genes are still there on the double helix, but RNA seems to play a powerful role in how genes function.

“This is potentially the biggest change in our understanding of biology since the discovery of the double helix,” said John S. Mattick, a professor of molecular biology at the University of Queensland in Australia.

Of course, as the article points out, there’s still a lot we don’t know, and there are likely to be unforeseen side effects until we understand how this all works much better. But this is a breakthrough in itself.

[Update a few minutes later]

Here’s an interesting article on how far genetics has come in the ninety-nine years since the word “gene” was coined.

[via Derbyshire, who has other thoughts]

Technology and Society

Mechanosynthesis

This seems like a pretty big breakthrough:

Working on a single atomic layer of tin atoms grown on a single-crystal silicon surface, the Japanese-European collaboration maneuvered an atomic force microscope (AFM) tip precisely (plus or minus 0.01 nm) over a single silicon atom defect in the tin surface, and were able to reversibly exchange a tin atom on the apex of the tip and the silicon atom on the surface. These experiments were done at room temperature and, unlike earlier demonstrations in which a scanning tunneling microscope (STM) tip was used to interchange atoms weakly bound to a metallic surface through use of an electrical bias, this demonstration used mechanical force to interchange strongly bound atoms.

Plenty of room at the bottom.

Science And Society, Technology and Society

When Are The Human Tests?

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A new drug that is a thousand times more powerful than resveratrol:

In the study, scientists fed the mice a high-fat, high-calorie diet mixed with doses of SRT1720 for approximately 10 weeks. The mice were given 100 or 500 milligrams of fat per kilogram of body weight each day (a high dose even for humans). The mice did not exercise regularly, although the scientists tested the animals’ exercise capacity, or endurance, by making them run on a treadmill. “The mice treated with the compound ran significantly longer,” says Auwerx. The drug also protected the animals from the negative effects of high-calorie diets: metabolic disorders, obesity-related diseases, and insulin resistance. It even improved the mice’s cholesterol.

It is significant that the drug mimics the effects of a calorie-restricted diet, since this has previously been tied to increased life expectancy, says William Evans, a professor of geriatric medicine, nutrition, and physiology at the University of Arkansas for Medical Sciences.

It’s as if the couch-potato mice underwent a strict diet and exercise regime, says David Sinclair, a biologist at Harvard Medical School, in Boston, who is one of the cofounders of Sirtris but was not involved in the current study. The new study “is a major step forward, showing that we can design and synthesize potent, druglike molecules that could slow down the aging process,” says Sinclair.

I think that people are going to be amazed at the life-extension and health advances coming along in the next few years. It makes it all the more the shame that we continue to lose people who we might save if they could just hang on long enough.