Category Archives: Business

A New Class Of Cholesterol Drugs

I wish I had more confidence that they’re not just treating a symptom:

As for the efficacy of the drugs, it is not yet proved that very low LDL levels produced by drugs lead to sharp reductions in heart attacks, strokes and deaths from cardiovascular disease, as researchers have seen in people with the naturally inactive PCSK9 gene.

Many cardiologists, though, are persuaded by a large body of evidence supporting the idea that the lower the LDL, the lower the risk.

“I believe lower is better and do not believe that a very low LDL is harmful,” said Dr. Daniel Rader, a cardiologist at the University of Pennsylvania.

Others, like Dr. Harlan Krumholz, a cardiologist at Yale, urge caution. “We are in a period of exuberant enthusiasm about these drugs,” he said. “We could just be performing cosmetic surgery on a lab value.”

If it were certain that the PCSK9 inhibitors were safe and effective in preventing heart attacks and deaths there would be no need for clinical trials, he noted.

$14,000/year is a lot of money for a treatment for which we have no idea whether or not it’s effective. I think improving diets would be much more cost effective.

[Update Tuesday morning]

Here’s a longer piece about the new drugs and the issues. Note: 1) It is assumed that the goal is to lower cholesterol, and that this will in turn result in lower mortality and 2) No mention of diet as a potential solution. Of course, it’s hard to get people to change their diets. But I suspect that to the degree that doctors are telling people to do so, they’re still telling them to cut out sat fat and cholesterol, despite all the actual science, and probably still telling them to follow FDA food-pyramic advice, which is junk science.

[Bumped]

Growing Metal Structure

like a tree:

Modumetal uses nanotechnology — manipulation of matter at the molecular level — to micromanage at a very small scale to better control the conditions and substances through which electroplating occurs. Basically, the company grows metal on a surface in a way that makes it easier to shape and tinker with the material’s characteristics. Lomasney says it’s similar to how nature controls the environment related to a tree’s growth— sunlight, soil, location, temperature—and then creates a tree that is a product those conditions.

This is the sort of thing that Eric talked about in Engines of Creation almost thirty years ago. It’s one of the reasons that any plans NASA has for Mars missions decades from now are already obsolete.

Fusion

A new breakthrough?

…burning hydrogen-boron fuel requires truly enormous temperatures, more than 3 billion degrees Celsius, and that will be “very challenging,” says plasma physicist Jon Menard of the Princeton Plasma Physics Laboratory in New Jersey, who is not involved in the project. He says it’s very hard to predict how the gas will behave at higher temperatures. “I’m a little concerned that their [simulations] lag behind their experience,” he says, but the approach “is worth further investigation.”

I hope that one of these ideas works out at some point.

Punching Back Twice As Hard On Campus

Instapundit has some good advice for a fraternity under siege:

(1) Immediately complain to the Department of Education and the Department of Justice that you’re being targeted because of your race and sex, and denied your First Amendment rights. No, nothing will come of this, but that’s not the point. The process is the punishment. (2) Sue on the same grounds. (3) The real killer: Go to the Virginia Legislature and tell them they should cut Old Dominion’s budget. Come prepared with figures on the number of administrators on campus now, versus 10 and 20 years ago. File freedom of information requests and get the travel expense figures for the folks in the administration. Look over them for suspicious and large expenditures. (You’ll find them!) Make a big stink about those.

Administrative bloat leads to large numbers of “student life” educrats without enough to do, so they’ve created a quasi-police-state to fill the time. State legislators are looking for things to cut anyway, and higher ed doesn’t have the clout it used to have. This will hurt them more than anything else you can do.

I would love to see that happen.