So I heard about this story on the news this morning, and it sounded a little junk sciency:
“What’s exciting about this is it takes that to another place,” said Toni Pollin, an associate professor of medicine at the University of Maryland School of Medicine, who led the 2008 work. “Just as you’d expect from something that prevents coronary artery buildup, there is strong evidence that having [a gene mutation] reduces the risk of having a heart attack.”
Kathiresan and colleagues benefited from the revolution in genome technology, sequencing 18,666 genes in each of 3,734 people in their search for genes that appeared to be linked to triglycerides. Rare mutations in the APOC3 gene stood out.
Once they understood where to look, they searched for four mutations in that gene in more than 110,000 people. They found that people with any one of the mutations — about 1 in 150 people — were 40 percent less likely to have heart disease and had lower levels of triglycerides.
There is no doubt in my mind that that there is a genetic basis for heart-disease risk, but I am not seeing anything in this study that would indicate that trying to reduce triglycerides per se (as statins attempt to lower cholesterol) are doing anything but treating a symptom, and possibly a harmless one. The mutation reduces both triglycerides and heart risk, but doesn’t mean that high triglycerides increase heart risk per se, or that lowering them artificially will reduce it.
But for what it’s worth, since I went partially paleo, my triglycerides have become almost immeasurable.