Many issues remain:

Since the 1960s – and following the Nuremberg trials – it has been standard practice for researchers to follow certain ethical standards in the treatment of human subjects. These rules include the requirement to submit research proposals to an ethics committee for prior approval, clearly explain clearly the risks of any procedures to potential research subjects, before obtaining their informed consent. Since Mars One now admits to planning research on the colonists themselves, the mission becomes bound to these same standards.

Mars One may not meet these conditions. As far as we know, no ethics committee has considered the Mars One plan or the risks it poses to the colonists. These risks will need to be communicated clearly before volunteers are recruited to take part in the mission.

I’ve previously expressed my own concerns, but I don’t agree that having it done by government space agencies instead is the solution, or that a disaster will inhibit human migration into space.