An interesting discussion branching off from questions about the benefits of resveratrol. It seems pretty clear to me that there’s no evolutionary pressure to live much past the time that your offspring (or perhaps grand-offspring) are off on their own. And that it violates no laws of physics to figure out how to cheat mother nature in that regard.

…through RNA interference:

In monkeys, a single injection of a drug to induce RNA interference against PCSK9 lowered levels of bad cholesterol by about 60 percent, an effect that lasted up to three weeks. Alnylam Pharmaceuticals, the biotechnology company that developed the drug, hopes to begin testing it in people next year.

The drug is a practical application of scientific discoveries that are showing that RNA, once considered a mere messenger boy for DNA, actually helps to run the show. The classic, protein-making genes are still there on the double helix, but RNA seems to play a powerful role in how genes function.

“This is potentially the biggest change in our understanding of biology since the discovery of the double helix,” said John S. Mattick, a professor of molecular biology at the University of Queensland in Australia.

Of course, as the article points out, there’s still a lot we don’t know, and there are likely to be unforeseen side effects until we understand how this all works much better. But this is a breakthrough in itself.

[Update a few minutes later]

Here’s an interesting article on how far genetics has come in the ninety-nine years since the word “gene” was coined.

[via Derbyshire, who has other thoughts]