Climate science has been thrown into disarray by the hiatus, disagreement between climate model and instrumental estimates of climate sensitivity, uncertainties in carbon uptake by plants, and diverging interpretations of ocean heating (in the face of a dearth of observations). ‘Certainty’ arguably peaked at the time of the AR4 (2007); perception of uncertainty is arguably greater than any time since the FAR (1991). Yes of course we know more about the climate system than we did in 1991, but more knowledge about the complex climate systems opens up new areas of ignorance and greater uncertainty.
In context of the way climate sensitivity is defined by the IPCC, uncertainty in climate sensitivity is decreasing as errors in previous observational estimates are identified and eliminated and model estimates seem to be converging more. Climate model simulations, when compared with 21st century observations seem to be running too hot, giving creedence to the lower observation-based sensitivity values.
What do the lower values of climate sensitivity imply for policy? Well slower values of warming make it easier to adapt, and provide time to develop new technologies and new policies. But the true believers such as Mann et al. call adaptation, developing new technologies and policies as ‘inaction.’ The policy logic apparent in the essays critical of my op-ed are rather naive.
So we are left with science in disarray and naive logic regarding policy. And the ‘warm team’ wonders why people are yawning?
Ketone esters are in a class of supplements called “generally recognized as safe” or GRAS by the FDA. They are expensive, difficult to find, and taste nasty (I’ve smelled some, and it was a bit like salty urine). There are no long term studies of the safety of these supplements in humans, though high ketone levels were maintained in severely obese, fasting patients for 6-8 weeks and there seemed to be no side effects. The main risk might be an exacerbation of gout, but truly, the long term consequences are unknown. For someone with dementia facing an inevitable downward spiral and life in a long term care facility, the question of benefits versus risk is a different calculation than in someone without that condition.
After a few days of escalating doses, Mr. Newport was brushing his own teeth, spontaneously dressing and bathing himself again, had improvements in mood, and was able to recite the alphabet. After 6-8 weeks, his memory improved and he started to do yard work again. After 20 months, he maintained definite improvement, with his cognitive function seeming to wax and wane with rising and falling ketone levels in his blood.
While this report is just a single case study, it does merit more clinical investigation. Given the severity and cost of the disease, the possibility of a far more effective treatment than what we currently have must be explored further.
It actually wouldn’t surprise me at all. Alzheimer’s may be just one more modern illness caused by the awful official dietary advice over the past six decades.