The Achilles Heel Of Aging

Most people aren’t aware of the recent scientific breakthroughs in life extension technology, but here’s a good update:

In 2004 my lab teamed up with Dr. Rafael de Cabo at the National Institutes of Health to see if resveratrol could improve the health and extend the lifespan of mice. When middle-aged mice were fed a low-fat diet, resveratrol delayed diseases of aging but did not extend lifespan. When fed a high-fat diet, mice on resveratrol got chubby but stayed healthy — they were less susceptible to diseases we associate with obesity, like type II diabetes. And with a sufficient- win a Nobel Prize. ly high resveratrol dose, they burned enough fat to stay lean. What’s more, the resveratrol mice on the high-fat diet ran twice as far on a treadmill as their unmedicated counterparts, and their remaining lifespan after treatment began increasing by an average of 25 percent compared with the high-fat controls. Notably, in both the obese and the lean mice on resveratrol, there was the clear physiological signature of calorie restriction.

The trouble is, while resveratrol is found in many foods, it is present only in very low concentrations. Someone wanting to get a resveratrol dose equivalent to what we used in our mice studies would need to consume hundreds of bottles of red wine each day. Resveratrol has served its purpose, proving the possibility of inducing the physiology of dieting and exercise with a small molecule. Now pharmaceutical companies are working on synthetic molecules that are thousands of times as potent as resveratrol: The race to develop a drug that targets sirtuins is on, though the longterm effect of activating sirtuins in humans requires further research. If the mice studies are anything to go by, the side effects of these drugs could include protection from multiple illnesses, including heart disease, osteoporosis, cataracts, and Alzheimer’s.

Bring it on. I’m all in favor of this, which is one of the reasons that I’m not a conservative.

Defending The EPA

Jonathan Adler thinks they have no choice:

By all means conservatives should object to the regulatory nightmare that the control of greenhouse gas emissions under the Clean Air Act will create. But this is a result of the Supreme Court’s reinterpretation of the Clean Air Act in Massachusetts v. EPA and the failure of Congress to amend the law or enact an alternative, not the Obama Administration.

I’m perfectly happy to blame Congress for it.

Confidence Building

Appropriately frightened CEOs are hampering the recovery:

The yield curve predicts growth. Check. Consumer sentiment is ticking up. Check. But CEO confidence is lousy, and CEOs are (not) spending accordingly. Whoops. This begs the question: Why are CEOs in such a low mood?

Answer: If you are a CEO in financial services, manufacturing, energy production and health care, you are going to be more regulated. Period, end of story. Your response to forthcoming regulation of yet-to-be-determined complexity will be to hunker down. Keep your name out of the news, improve the balance sheet and hold tight.

This is why the U.S. economy, which wants to turn the corner, is still stuck in the intersection as it decides which way to go.

In her book The Forgotten Man, Amity Shlaes (now a Forbes columnist) wrote that the 1937-38 “depression within a depression” occurred when “capital went on strike.” President Roosevelt’s willingness to “try anything”–including retroactive taxation, laws against discount pricing and an attempted Supreme Court packing–had businesses and their backers so confused about Roosevelt’s rules that they simply withdrew.

This is the risk of Obama’s willingness to “do what it takes.” The words sound positive and action-oriented. But in practice, “do what it takes” really means “anything can happen.” Tearing up of legal contracts … that can happen. Limits to salary and travel … that can happen. Bullying by the Environmental Protection Agency … that can happen. Nationalization of General Motors and Citigroup … that can happen. Nobody knows for sure. Government is sorting it out, day by day.

I’d be happy to triple Congressional salaries, if they wouldn’t come in to “work.”

Confusing

Andy Pasztor has an article at the Journal today about NASA’s budget problems that is very misleading in its use of the word “Constellation.” For instance:

By casting doubt on Constellation’s progress, the report may provide ammunition for lawmakers and others hoping to extend the life of the shuttle past its current retirement date of 2010. Extending the life of the shuttle could reduce the gap between the last shuttle flight and the initial operation of Constellation. Lockheed Martin Corp. is the prime contractor for the project.

No, Lockheed Martin is not the prime contractor for Constellation, which consists of a number of system elements, starting with the Ares 1 launcher and Orion capsule. LM is only prime for the Orion. ATK is the lead for the Ares 1.

And then he writes:

Accelerating Constellation to 2013, as some inside NASA have advocated, would require significantly larger budget hikes, according to the report. NASA officials project the total cost for Constellation at around $30 billion

It’s not “accelerating Constellation,” which won’t be complete for many years, as it includes things like the Ares V heavy lifter, earth departure stages, the Altair lunar lander, etc., development of which haven’t even begun. It’s only accelerating Ares/Orion, which is what is required to close the dreaded “gap” (assuming that they don’t instead just do COTS D and hope that SpaceX comes through with Falcon 9 and Dragon).

And there’s no way that the total cost for “Constellation” will be only thirty billion. The GAO recently estimated that Ares 1 alone is going to cost at least seventeen billion, and Orion was going to cost at least twenty, with top estimates of twenty and twenty-nine respectively, which would mean close to fifty billion for Ares/Orion alone (and that’s just development costs — it excludes operations).

With all the numbers floating around out there, it’s easy to get things confused, but the words do mean things. Ares/Orion are not Constellation — they are a subset of it and only the first planned elements.

Lies, Damned Lies…

…and Mexican gun violence:

Obama is right that the U.S. is largely responsible for the carnage in Mexico, which claimed more than 6,000 lives last year. But the problem is neither the drugs Americans buy nor the guns they sell; it’s the war on drugs our government insists the rest of the world help it fight. Instead of acknowledging the failure of drug control, the Obama administration is using it as an excuse for an equally vain attempt at gun control.

And the administration continues to lie about the percentage of Mexican guns that come from the US, and much of the media ignorantly (or otherwise) repeat it.

Cry For England

Is Britain is becoming a soft totalitarian state?

The Government is pushing ahead with legislation that will criminalise politically incorrect jokes, with a maximum punishment of up to seven years’ prison. The House of Lords tried to insert a free-speech amendment, but Justice Secretary Jack Straw knocked it out. It was Straw who previously called for a redefinition of Englishness and suggested the “global baggage of empire” was linked to soccer violence by “racist and xenophobic white males”. He claimed the English “propensity for violence” was used to subjugate Ireland, Scotland and Wales, and that the English as a race were “potentially very aggressive”.

In the past 10 years I have collected reports of many instances of draconian punishments, including the arrest and criminal prosecution of children, for thought-crimes and offences against political correctness.

Countryside Restoration Trust chairman and columnist Robin Page said at a rally against the Government’s anti-hunting laws in Gloucestershire in 2002: “If you are a black vegetarian Muslim asylum-seeking one-legged lesbian lorry driver, I want the same rights as you.” Page was arrested, and after four months he received a letter saying no charges would be pressed, but that: “If further evidence comes to our attention whereby your involvement is implicated, we will seek to initiate proceedings.” It took him five years to clear his name.

Page was at least an adult. In September 2006, a 14-year-old schoolgirl, Codie Stott, asked a teacher if she could sit with another group to do a science project as all the girls with her spoke only Urdu. The teacher’s first response, according to Stott, was to scream at her: “It’s racist, you’re going to get done by the police!” Upset and terrified, the schoolgirl went outside to calm down. The teacher called the police and a few days later, presumably after officialdom had thought the matter over, she was arrested and taken to a police station, where she was fingerprinted and photographed. According to her mother, she was placed in a bare cell for 3 1/2 hours. She was questioned on suspicion of committing a racial public order offence and then released without charge. The school was said to be investigating what further action to take, not against the teacher, but against Stott. Headmaster Anthony Edkins reportedly said: “An allegation of a serious nature was made concerning a racially motivated remark. We aim to ensure a caring and tolerant attitude towards pupils of all ethnic backgrounds and will not stand for racism in any form.”

A 10-year-old child was arrested and brought before a judge, for having allegedly called an 11-year-old boya “Paki” and “bin Laden” during a playground argument at a primary school (the other boy had called him a skunk and a Teletubby). When it reached the court the case had cost taxpayers pound stg. 25,000. The accused was so distressed that he had stopped attending school. The judge, Jonathan Finestein, said: “Have we really got to the stage where we are prosecuting 10-year-old boys because of political correctness? There are major crimes out there and the police don’t bother to prosecute. This is nonsense.”

And yet it persists. It’s frightening. And don’t think we’re not on the way there ourselves.

Americorps Expansion

One of the many bad legacies of the Clinton administration is Americorps. Nick Gillespie as a righteous rant about the administration’s plans to expand it:

A few things regarding this piece of self-congratulatory lard every bit as bloated and morally compromised as the man for whom it is named (as it happens, Obama seemed to be confusing Teddy K with JFK, proclaiming “”I want all Americans to take up that spirit of the man for whom this bill is named; of a president who sent us to the moon; of a dreamer who always asked ‘Why not?'”).

First, public or national service is profoundly un-American as a historical concept and comes always and everywhere slathered in the stink of trench warfare and rhetorical horseshit. This is especially true when it is paid service even as those participating and spending your tax dollars luxuriate in the silky-smooth language of altruism. Which, last time I checked, was supposed to be free. Jesus rendered unto Caesar; he didn’t ask for a block grant from Pontius Pilate in return. That Obama pushes national service and voluntarism even as he works to limit tax breaks for charitable giving that drives all sorts of philanthropy is a classic screw-you, my-way-or-the-highway move.

Second, AmeriCorps is a program with a long and distinguished history of sucking even by government standards. It effectively comes in second to the standard-issue DMV bureau, with its director in 2003 dubbing it “another cumbersome, unpredictable government bureaucracy.” Yeah, yeah, they can fix all that and become squeaky clean, yadda yadda yadda, and that still doesn’t address the more basic fact that it is at best superfluous to what Americans, young and old, are already doing: Which is volunteering and “giving back” to the community up the ying-yang.

And to the extent that laws such as this confuse actual contributions to increasing living standards with getting some sort of paycheck from a non-essential government agency, they do far more damage to American ideals than we normally admit. As Julian Sanchez wrote here a few years back, “AmeriCorps boosters are less interested in the good works that serve as the program’s public justification than in the grand sense of national community it’s meant to inspire. Without AmeriCorps, after all, young people might conclude that they’re perfectly capable of giving back to their communities without either the assistance or the direction of the federal government. And wouldn’t that be a tragedy.”

A good general rule of thumb is that anything that Ted Kennedy thinks is a good idea is probably appallingly bad.

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