An interesting new theory, for those well versed in organic chemistry.
[Update in the afternoon]
This seems related:
Not content with achieving one hallmark of life in the lab, Joyce and Lincoln sought to evolve their molecule by natural selection. They did this by mutating sequences of the RNA building blocks, so that 288 possible ribozymes could be built by mixing and matching different pairs of shorter RNAs.
What came out bore an eerie resemblance to Darwin’s theory of natural selection: a few sequences proved winners, most losers. The victors emerged because they could replicate fastest while surrounded by competition, Joyce says.
“I wouldn’t call these molecules alive,” he cautions. For one, the molecules can evolve only to replicate better. Reproduction may be the strongest – perhaps only – biological urge, yet even simple organisms go about this by more complex means than breakneck division. Bacteria and humans have both evolved the ability to digest lactose, or milk sugar, to ensure their survival, for instance.
Joyce says his team has endowed its molecule with another function, although he will not say what that might be before his findings are published.
More fundamentally, to mimic biology, a molecule must gain new functions on the fly, without laboratory tinkering. Joyce says he has no idea how to clear this hurdle with his team’s RNA molecule. “It doesn’t have open-ended capacity for Darwinian evolution.”
Not yet.