This looks like an interesting approach, but I’m skeptical until I better understand what the rodents were actually fed. A “western high-fat diet” is a meaningless phrase. What kind of fats? Saturated? Seed oils? There is no scientific evidence that eating fat per se creates arterial plaque. How many and what kind of carbs were they getting?
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And dietary fat is a very, very small contributor to serum cholesterol: Carbohydrates (especially but not only) simple sugars are the primary contributor.
Want to reduce serum cholesterol? Take up a low carb diet.
I bet a “western high fat diet” is eating a Big Mac, French Fries, and a milkshake at every meal. There’s no evidence that eating cholesterol causes you to have high cholesterol in your blood stream either, But that hasn’t stopped the march of “science.”
Also worth considering that mice are adapted to a natural diet that has barely any fats, especially saturated fats.
Good point.
I can neither take credit nor remember where I first heard that. It seems simple and obvious in hindsight yet it implies that a huge proportion of biomedical research cannot be relied upon.
That is absolutely true.
It looks like you have stumbled upon a market opportunity. How are you at gene splicing? Fauci will be looking for a job soon and whoever hires him is sure to get lots of government contracts.
Fauci will be looking for a job soon and whoever hires him is sure to get lots of government contracts.
Thinking about genetically engineering Marburg virus to gain the function of a plaque removing virus? Fauci is your man. Just ignore the hemorrhaging and high fevers. Those are just a side effect.
Nah. These are mice that identify as human.
So I can kill mice by feeding them hydrogenation-process peanut butter?
I tried that on my mice. They threatened to sic the spiders on me.
FC, I think there was a trial on rabbits that had the same problem.